Frustratingly enough, there's no production history about this movie on Wikipedia or the Hannibal Lecter wiki and I couldn't find a making of featurette with any worthwhile information so I had to get creative and look up production information from way back in 2001 and 2002. Even before the release of Hannibal, Dino and Martha de Laurentiis announced that they were going to remake Red Dragon, emphasizing that Lecter's role in the story would be expanded and there were rumours that Ridley Scott would be back to direct it. Manhunter's critical reevaluation had surged by this point, with even more popularity coming its way with the premiere of CSI and there was some discontent at the idea of remaking the film less than 20 years later. However, given the more than 10 year gap between the publication of The Silence of the Lambs and Manhunter, it was obvious that no new Hannibal Lecter material was going to be produced any time soon so they needed to cash in somehow.
Hannibal's tepid response had soured many critics on the prospect of another outing though, with some saying that he had become a joke and moved into the realm of camp. Perhaps because of this, Ridley Scott didn't return for Red Dragon and the project pivoted in a more serious direction, more akin to The Silence of the Lambs' tone. As if to confirm this direction, Ted Tally returned to write the script after skipping Hannibal due to his objections to the novel's story. It was even rumoured that Jodie Foster may make a cameo appearance, despite the fact that Red Dragon was supposed to take place ten years prior to The Silence of the Lambs and everyone involved had noticeably aged in the interim (an obvious issue which the de Laurentiis brushed off casually). An issue which may have scuppered this idea was that MGM still held the rights to characters exclusive to The Silence of the Lambs, while Red Dragon was exclusively being distributed by Universal.
By the fall of 2001, human garbage pile Brett Ratner (of Rush Hour fame) had signed on to direct the film and a plethora of talent flocked to Tally's script, including Edward Norton as Will Graham, Emily Watson as Reba McClane, Harvey Keitel as Jack Crawford and Philip Seymour Hoffman as Freddie Lounds. Hopkins, of course, would return as Hannibal Lecter, having secured himself an $8 million payday plus 7.5% of the film's profits for a role that is essentially an extended cameo. That just left the role of Francis Dolarhyde in the air. While Sean Penn was in early talks to play the role, Ratner wanted Ralph Fiennes, known at the time for dramatic roles in The English Patient and The End of the Affair, as well as being the antagonist in Schindler's List. In December of 2001, Fiennes won the role and started a hardcore workout regimen to try to get himself into shape - Dolarhyde was supposed to be an intimidating bodybuilder-type and Fiennes (who describes his body shape as "slight") had only a month until shooting began to bulk up, especially because he is completely nude for several of his scenes.
Also worth noting was the return of Manhunter cinematographer Dante Spinotti, who Ratner wanted so badly that he delayed production of the film in order to wait for Spinotti's schedule to open up. While some people questioned by Spinotti would try to shoot the exact same story again, he clarified that he felt like Ted Tally's script changed the feel of the movie; it was more faithful to the book and had a more realistic, grounded style. Faithfulness to the book also extended to the shooting, with Ratner filming on location in the book's environs as much as possible. Production designer Kristi Zea, who had worked on The Silence of the Lambs, was also brought back to try to give Red Dragon a similar feel.
The film released on October 4, 2001 and, while it did fairly well and received mostly positive reviews, it ended up grossing only $209.1 million, a little more than half the numbers Hannibal raked in. It seemed like Lecter fatigue had well and truly set in...